reviewed
subscriptions
Prescription
PT-141 Combo
No subscriptions. Order as you need.
2,000+ patients served
Contains tadalafil. Never use with nitrates, “poppers” or riociguat. Safety information.
No visit fee. You’re only charged if a provider approves. One-time purchase. Shipping included. Prescription subject to provider approval.
- Shipping included
- Ships within 1 to 2 business days of approval
- Provider reviewed
Find the right fit
for your sex life.
Compare PT-141 Combo with sildenafil and tadalafil.
| Comparison feature |  PT-141Combo |  Sildenafil |  Tadalafil |
|---|---|---|---|
| Better erection quality | Yes | Yes | Yes |
| More sexual desire | Yes | No | No |
| Less performance anxiety | Yes | No | No |
| Greater emotional connection | Yes | No | No |
| Fast-acting (30–60 min) | Yes | Yes | No |
| Works without sexual stimulation | Yes | No | No |
| Multiple active ingredients | Yes | No | No |
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I wanted to get a face cream. I was looking for this type of cream for a while and this website has the best price. I ordered and it was a very easy a quick process. I filled out the questionnaire, received a quick approval, paid for the product and received it within 2 days. Great service. Thank you
Great job. Quick response.
I noticed I put the wrong number in my address after I already sent everything. Thought for sure that was going to be a mess. Sent them a message and they fixed it before it shipped. They even let me know it was corrected so I wasn’t sitting there worrying about it.
No surprises at checkout
I liked that I didn’t have to hunt around for the real price. Everything was shown upfront and what I saw was what I paid.
A Truly Positive and Professional Personal Experience
Based on my personal experience, Signal-Rx provides exceptional service and outstanding products, backed by a team that is remarkably knowledgeable, professional, and polite.
How it works
Three steps.
No ongoing commitment.
Get prequalified in 2 minutes.
Share your health history, intimacy goals and current medicines online.
Check out. Pay nothing yet.
Your card is only held, not charged. Then verify your ID and answer a few last health questions.
Approved? It ships.
A licensed provider reviews every request within 24 hours. You’re only charged if approved: the tablets, shipping included. A one-time purchase, never a subscription.
One tablet. Your intimacy goals.
Each compounded dissolvable tablet contains PT-141 2 mg, tadalafil 20 mg and oxytocin 100 IU. Bring your goals for desire, arousal and physical response into one provider review. Your provider considers your health history and current medicines before deciding whether this formula is appropriate.
Desire
Talk about changes in sexual interest and what you want to address.
Arousal
Describe how engaged you feel and any changes you have noticed.
Physical response
Share whether your body responds as you expect, including any erection concerns.
Before you start
PT-141 Combo FAQs.
What happens after I start?
Answer a few quick health questions online. It takes about 2 minutes and it’s free. Then check out once: your card is only held, not charged. Verify your ID and answer a few last health questions, and a licensed provider reviews your request within 24 hours. If approved, you’re charged and your PT-141 Combo ships. If nothing is approved, you cancel, or the hold expires, the hold is released, so there is nothing to refund. A prescription is not guaranteed.
What does the medication price cover?
10 tablets for $150. Every supply has the same formula per tablet, with standard shipping included. There’s no visit fee. You’re only charged if a provider approves.
Is this a subscription?
No. There are no subscriptions or automatic refills. You choose when to request another order. Every order still requires provider approval.
How is PT-141 Combo different from tadalafil or sildenafil alone?
PT-141 Combo contains three ingredients per dissolvable tablet: PT-141 2 mg, tadalafil 20 mg and oxytocin 100 IU. Tadalafil-only and sildenafil-only options contain one active ingredient. Your provider can discuss which option fits your health history and goals. The three-ingredient combination is compounded and is not FDA-approved.
How do I use it, and can I combine it with another ED medication?
Follow the pharmacy label for the amount, timing and frequency. Do not split a tablet unless the prescriber or pharmacy directs you. PT-141 Combo already contains tadalafil. Do not combine it with tadalafil, sildenafil or another erectile-dysfunction treatment unless your prescriber specifically directs you to.
How is it delivered?
Shipping is included. It ships within 1 to 2 business days of approval, and most orders arrive within 2 business days after they ship. Follow the pharmacy label for storage and handling.
See important safety information
PT-141 Combo is a compounded dissolvable tablet containing PT-141 2 mg, tadalafil 20 mg, and oxytocin 100 IU. Use it only in the amount, at the time, and with the frequency shown on your pharmacy label. The listed 20 mg is the tadalafil content in each tablet—not a universal dose or schedule.
Do not use with these medicines
Never use PT-141 Combo with nitrate medicines, including nitroglycerin or isosorbide; recreational nitrites commonly called “poppers”; or riociguat. These combinations can cause a dangerous drop in blood pressure. Do not combine it with tadalafil, sildenafil, another PDE5 inhibitor, or another erectile-dysfunction treatment unless your prescriber directs you.
Heart and blood-pressure screening
Do not use if you have uncontrolled high blood pressure or known cardiovascular disease, or if a clinician has said sexual activity is unsafe for your heart. PT-141 can affect blood pressure and heart rate. Tell the provider about heart or blood-vessel disease, blood-pressure concerns, chest pain, fainting, stroke history, or cardiovascular symptoms during sex.
What to tell the provider
Disclose every condition, allergy, medicine, and supplement. Include kidney or liver problems, eye or hearing conditions, bleeding problems, penile curvature, or prolonged erections. Specifically mention alpha blockers, blood-pressure medicines, CYP3A4-interacting medicines, naltrexone, and sexual-health treatments. Substantial alcohol use can increase dizziness and low-blood-pressure symptoms with tadalafil.
Pregnancy and breastfeeding
Tell the provider if you are pregnant, may be pregnant, are trying to become pregnant, or are breastfeeding. Stop use and contact the prescriber if pregnancy is suspected. PT-141 or bremelanotide is not recommended during pregnancy, and oxytocin can affect uterine activity.
Possible effects
Ingredient-associated effects may include nausea, flushing, headache, dizziness, vomiting, indigestion, nasal congestion, back or muscle discomfort, and changes in blood pressure or heart rate. PT-141 has also been associated with focal skin darkening that may not fully resolve. Contact the provider about persistent, severe, or worsening effects or new pigmentation. Reaction frequency for this exact combination is not established.
When to seek urgent care
Stop sexual activity and seek immediate care for chest pain, severe dizziness, fainting, or nausea during sex. Get emergency help for an erection lasting more than four hours, sudden vision or hearing decrease or loss, severe allergy, or any severe or rapidly worsening reaction. Tell emergency clinicians when the medication was last used.
Storage and disposal
Store and handle the tablets as directed on the pharmacy label. Keep them away from children, do not share them, and do not use them after the labeled beyond-use date. Ask the pharmacy how to dispose of unused medication.
Compounded-medication disclosure
PT-141 Combo and its dissolvable three-ingredient formulation are compounded prescription medication and are not FDA-approved. FDA does not review compounded drugs for safety, effectiveness, or quality before marketing. This product is not Vyleesi, is not an FDA-approved tadalafil product, and should not be treated as interchangeable with either. Read the FDA’s information about compounded drugs.